Intrathecal oligoclonal IgG synthesis in multiple sclerosis

J Neuroimmunol. 2013 Sep 15;262(1-2):1-10. doi: 10.1016/j.jneuroim.2013.06.014. Epub 2013 Jul 26.

Abstract

The diagnosis of multiple sclerosis is based on dissemination in time and space. Before 2010 lack of evidence for dissemination in space could be substituted by a paraclinical test, cerebrospinal fluid (CSF) oligoclonal bands (OCBs). The present meta-analysis (13,467 patients) shows that the diagnostic specificity of OCB drops from 94% to 61% if inflammatory etiologies are considered. Importantly, this was not caused by poor laboratory practice. This review on CSF OCB further illustrates the conceptional problem of substituting dissemination in space with a biomarker. The potential prognostic value of intrathecal OCB will need to be tested prospectively.

Keywords: Cerebrospinal fluid; Diagnostic criteria; Multiple sclerosis.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • B-Lymphocyte Subsets / immunology
  • B-Lymphocyte Subsets / metabolism
  • Biomarkers / cerebrospinal fluid
  • Humans
  • Multiple Sclerosis / cerebrospinal fluid*
  • Multiple Sclerosis / immunology*
  • Multiple Sclerosis / metabolism
  • Oligoclonal Bands / biosynthesis*
  • Oligoclonal Bands / cerebrospinal fluid*

Substances

  • Biomarkers
  • Oligoclonal Bands