Just a trim, please: refining ER degradation through deubiquitination

Cell. 2013 Aug 1;154(3):479-81. doi: 10.1016/j.cell.2013.07.008. Epub 2013 Jul 25.


ER-associated degradation clears the secretory pathway of misfolded proteins and mediates the regulated degradation of some ER resident proteins. Only a minor increase in the interaction between a protein and a ubiquitin ligase is sufficient to signal substrate degradation. Zhang et al. have identified deubiquitination as a signal amplifier.

Publication types

  • Comment

MeSH terms

  • Endopeptidases / metabolism*
  • Endoplasmic Reticulum / metabolism*
  • Humans
  • Membrane Proteins / metabolism*


  • Membrane Proteins
  • Endopeptidases