Meldonium decreases the diet-increased plasma levels of trimethylamine N-oxide, a metabolite associated with atherosclerosis

J Clin Pharmacol. 2013 Oct;53(10):1095-8. doi: 10.1002/jcph.135. Epub 2013 Jul 25.
No abstract available

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Atherosclerosis
  • Cardiovascular Agents / pharmacology*
  • Carnitine / metabolism
  • Diet
  • Female
  • HEK293 Cells
  • Humans
  • Male
  • Methylamines / blood*
  • Methylamines / urine
  • Methylhydrazines / pharmacology*
  • Organic Cation Transport Proteins / metabolism
  • Seafood
  • Solute Carrier Family 22 Member 5

Substances

  • Cardiovascular Agents
  • Methylamines
  • Methylhydrazines
  • Organic Cation Transport Proteins
  • SLC22A5 protein, human
  • Solute Carrier Family 22 Member 5
  • 3-(2,2,2-trimethylhydrazine)propionate
  • trimethyloxamine
  • Carnitine