Rapidly-dissolvable microneedle patches via a highly scalable and reproducible soft lithography approach

Adv Mater. 2013 Sep 25;25(36):5060-6. doi: 10.1002/adma.201300526. Epub 2013 Jul 29.

Abstract

Microneedle devices for transdermal drug delivery have recently become an attractive method to overcome the diffusion-limiting epidermis and effectively transport therapeutics to the body. Here, we demonstrate the fabrication of highly reproducible and completely dissolvable polymer microneedles on flexible water-soluble substrates. These biocompatible microneedles (made by using a soft lithography process known as PRINT) showed efficacy in piercing both murine and human skin samples and delivering a fluorescent drug surrogate to the tissue.

Keywords: PRINT; drug delivery; microneedles; microprojections; soft lithography.

Publication types

  • Research Support, Non-U.S. Gov't