The S100A8/A9 complex reduces CTLA4 expression by immature myeloid cells: Implications for pancreatic cancer-driven immunosuppression

Daniela Basso; Paola Fogar; Mario Plebani

doi:10.4161/onci.24441

The S100A8/A9 complex reduces CTLA4 expression by immature myeloid cells: Implications for pancreatic cancer-driven immunosuppression

Oncoimmunology. 2013 Jun 1;2(6):e24441. doi: 10.4161/onci.24441. Epub 2013 May 9.

Authors

Daniela Basso¹, Paola Fogar, Mario Plebani

Affiliation

¹ Department of Laboratory Medicine; University-Hospital of Padova; Padova, Italy.

Abstract

An expansion of different myeloid derived suppressive cell (MDSC) subsets can be detected in the blood and secondary lymphoid organs of early and advanced pancreatic ductal adenocarcinoma (PDAC) patients. Double negative (CD14^-HLA-DR^-) MDSCs are frequently induced by PDACs. In addition, by releasing S100A8 and S100A9, advanced PDAC lesions cause an expansion of highly immunosuppressive CD33⁺CD14⁺HLA-DR^- monocytic MDSCs expressing low levels of cytotoxic T lymphocyte antigen 4 (CTLA4) on the cell surface.

Keywords: CD8+ T cells; CTLA4; PDL1; S100 proteins; dendritic cells; myeloid-derived suppressive cells; pancreatic ductal adenocarcinoma.