Role of the sodium channel SCN9A in genetic epilepsy with febrile seizures plus and Dravet syndrome

Epilepsia. 2013 Sep;54(9):e122-6. doi: 10.1111/epi.12323. Epub 2013 Jul 29.


Mutations of the SCN1A subunit of the sodium channel is a cause of genetic epilepsy with febrile seizures plus (GEFS(+) ) in multiplex families and accounts for 70-80% of Dravet syndrome (DS). DS cases without SCN1A mutation inherited have predicted SCN9A susceptibility variants, which may contribute to complex inheritance for these unexplained cases of DS. Compared with controls, DS cases were significantly enriched for rare SCN9A genetic variants. None of the multiplex febrile seizure or GEFS(+) families could be explained by highly penetrant SCN9A mutations.

Keywords: Clinical heterogeneity; Dravet syndrome; Febrile seizures; Genetic epilepsy with febrile seizures plus; Genetic modifier; Genetic susceptibility; SCN1A; SCN9A; Susceptibility gene.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Epilepsies, Myoclonic / genetics*
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Mutation / genetics*
  • NAV1.7 Voltage-Gated Sodium Channel / genetics*
  • Pedigree
  • Seizures, Febrile / genetics*
  • Sodium Channels / genetics*


  • NAV1.7 Voltage-Gated Sodium Channel
  • SCN9A protein, human
  • Sodium Channels