Nerve physiology: mechanisms of injury and recovery

Hand Clin. 2013 Aug;29(3):317-30. doi: 10.1016/j.hcl.2013.04.002.

Abstract

Peripheral nerve injuries are common conditions, with broad-ranging groups of symptoms depending on the severity and nerves involved. Although much knowledge exists on the mechanisms of injury and regeneration, reliable treatments that ensure full functional recovery are scarce. This review aims to summarize various ways these injuries are classified in light of decades of research on peripheral nerve injury and regeneration.

Keywords: Nerve injury; Nerve physiology; Nerve recovery; Peripheral nerve injuries.

Publication types

  • Review

MeSH terms

  • Animals
  • Axons / physiology
  • Cells, Cultured
  • Humans
  • Macrophages / physiology
  • Models, Animal
  • Models, Biological
  • Nerve Compression Syndromes / etiology
  • Nerve Compression Syndromes / physiopathology
  • Nerve Fibers / physiology
  • Nerve Growth Factors / metabolism
  • Nerve Regeneration / physiology*
  • Neurons / metabolism
  • Peripheral Nerve Injuries / classification
  • Peripheral Nerve Injuries / etiology
  • Peripheral Nerve Injuries / physiopathology*
  • Peripheral Nerves / anatomy & histology
  • Peripheral Nerves / physiology*
  • Schwann Cells / physiology
  • Wallerian Degeneration / physiopathology

Substances

  • Nerve Growth Factors