Viral hepatitis: Cell-culture-derived HCV--a promising vaccine antigen

Nat Rev Gastroenterol Hepatol. 2013 Sep;10(9):508-9. doi: 10.1038/nrgastro.2013.136. Epub 2013 Jul 30.


With millions of humans infected yearly with HCV, leading to cirrhosis and cancer, a vaccine is urgently needed. Cultured virus particles constitute the antigen in most antiviral vaccines. A study in mice demonstrated induction of neutralizing antibodies by immunization with cell-culture-derived HCV, providing new possibilities for vaccine development.

Publication types

  • News
  • Comment

MeSH terms

  • Animals
  • Antibodies, Neutralizing / immunology*
  • Female
  • Hepatitis C / prevention & control*
  • Hepatitis C Antibodies / immunology*
  • Humans
  • Immunization*
  • Viral Hepatitis Vaccines / immunology*


  • Antibodies, Neutralizing
  • Hepatitis C Antibodies
  • Viral Hepatitis Vaccines