About 12 000 women of childbearing age sustain spinal cord injuries each year in the United States. Around 2000 of these women become pregnant in a given year, yet few providers are aware of the interprofessional team approach needed to achieve a successful pregnancy with healthy outcomes for both mother and fetus. A family-centered approach by an experienced team can make the childbearing experience both safe and optimal for the maternal-fetal dyad. The challenges related to caring for women with spinal cord injury during pregnancy, including skin breakdown, urinary tract infections, respiratory compromise, bowel motility, depression/anxiety, preterm labor, and autonomic dysreflexia, are reviewed.