Panniculitis with vasculitis

G Ital Dermatol Venereol. 2013 Aug;148(4):387-94.


Panniculitides encompass a great number of different entities; however, once a vasculitis has been detected histopathologically within the subcutaneous tissue, the differential diagnosis is mainly restricted to polyarteritis (panarteritis) nodosa (PAN), nodular vasculitis (NV), and Bazin's erythema induratum (EI). Patients with PAN may have the disease confined to the skin, but must be followed over a long period because many of them develop late systemic disease. The NV/EI group represents by far the most common type of lobular panniculitis with vasculitis; we prefer keeping the distinction between the two entities by underlining the equation NV positive tuberculin skin test = EI. Other lobular panniculitides with vasculitis are exceedingly rare and set in a systemic background which can be infectious (lepromatous leprosy panniculitides) or autoimmune/dysreactive (neutrophilic lobular panniculitis in rheumatoid arthritis, lobular panniculitis in inflammatory bowel disease).

Publication types

  • Review

MeSH terms

  • Arthritis, Rheumatoid / complications
  • Disease Progression
  • Erythema Induratum / diagnosis
  • Erythema Induratum / pathology
  • Humans
  • Inflammatory Bowel Diseases / complications
  • Leprosy, Lepromatous / complications
  • Panniculitis / complications*
  • Panniculitis, Nodular Nonsuppurative / diagnosis
  • Panniculitis, Nodular Nonsuppurative / pathology
  • Polyarteritis Nodosa / diagnosis
  • Polyarteritis Nodosa / pathology
  • Subcutaneous Fat / blood supply
  • Subcutaneous Fat / pathology
  • Thrombophlebitis / pathology
  • Vasculitis / complications*
  • Vasculitis, Leukocytoclastic, Cutaneous / diagnosis
  • Vasculitis, Leukocytoclastic, Cutaneous / pathology

Supplementary concepts

  • Erythema elevatum diutinum