Abstract
A series of bis(oxazolidine)pyridine ligands (the PyBodines) were newly designed and synthesized for the development of a highly efficient, tailor-made catalyst for the [3+2] cycloaddition of azomethine imines with propiolates. The PyBodine(l-Ala)-Cu(OAc)2 catalyst was selected on the basis of solid-phase catalysis/CD-HTS and exhibited high efficiency, producing the (R)-adducts with excellent enantioselectivity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkynes / chemistry*
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Azo Compounds / chemistry*
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Catalysis
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Cycloaddition Reaction
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Imines / chemistry*
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Ligands
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Metals / chemistry*
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Oxazoles / chemistry
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Propionates / chemistry*
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Pyridines / chemistry*
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Stereoisomerism
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Thiosemicarbazones / chemistry*
Substances
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Alkynes
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Azo Compounds
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Imines
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Ligands
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Metals
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Oxazoles
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Propionates
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Pyridines
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Thiosemicarbazones
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azomethine
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oxazolidine
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pyridine
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propiolic acid