Magnesium deficiency-induced cardiomyopathy: protection by vitamin E

Biochem Biophys Res Commun. 1990 Aug 16;170(3):1102-6. doi: 10.1016/0006-291x(90)90506-i.


Syrian male hamsters weighing 80-100g were placed on either a magnesium deficient diet (MgD) or an identical diet supplemented with 100 mmols/Kg MgCl. Animals from each group received vitamin E 10, 15, and 25mg three-week slow release pellets, as subcutaneous implants. The animals were sacrificed after 14 days and their hearts isolated for morphological analysis. H&E stained sections were examined by a computer image analysis system for a morphometric determination of the severity of myocardial injury. Vitamin E significantly (p less than 0.01) reduced both the numerical density and the area fraction of MgD lesions. These data indicate possible free radical participation in the mechanism of injury.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cardiomyopathies / etiology
  • Cardiomyopathies / pathology
  • Cardiomyopathies / prevention & control*
  • Cricetinae
  • Magnesium Deficiency / complications*
  • Male
  • Mesocricetus
  • Myocardium / pathology
  • Vitamin E / therapeutic use*


  • Vitamin E