Molecular cloning of guinea-pig aromatic-L-amino acid decarboxylase cDNA

Biochem Biophys Res Commun. 1990 Aug 16;170(3):1229-35. doi: 10.1016/0006-291x(90)90525-r.

Abstract

Guinea-pig aromatic-L-amino acid decarboxylase (DOPA decarboxylase, DDC), but not rat DDC, reacts with the antibody against rat histidine decarboxylase (HDC). For determination of the molecular reaction for this cross-reactivity, a cDNA clone of guinea-pig DDC was isolated. Guinea-pig DDC consists of 480 amino acids and its molecular weight is 54,148. The sequence identify of guinea-pig DDC with rat DDC is 86%. Guinea-pig DDC has a region showing 100% sequence identity with rat HDC, but only 67% sequence identity with rat DDC, suggesting that this region is related with the cross-reactivity of guinea-pig DDC and anti-rat HDC antibody.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Aromatic-L-Amino-Acid Decarboxylases / genetics*
  • Base Sequence
  • Cloning, Molecular*
  • Cross Reactions
  • DNA / genetics*
  • DNA, Recombinant / analysis*
  • Dopa Decarboxylase / analysis
  • Dopa Decarboxylase / genetics*
  • Dopa Decarboxylase / immunology
  • Guinea Pigs
  • Histidine Decarboxylase / analysis
  • Histidine Decarboxylase / immunology
  • Molecular Sequence Data
  • Rats
  • Restriction Mapping

Substances

  • DNA, Recombinant
  • DNA
  • Dopa Decarboxylase
  • Histidine Decarboxylase
  • Aromatic-L-Amino-Acid Decarboxylases

Associated data

  • GENBANK/M58049