A randomized, double-blind, placebo-controlled clinical trial to investigate the effect of Cynatine(®) HNS on skin characteristics

Int J Cosmet Sci. 2013 Dec;35(6):608-12. doi: 10.1111/ics.12084. Epub 2013 Sep 2.


Objective: A new, novel product, Cynatine(®) HNS was evaluated for its effects as a supplement for improving various aspects of skin in a randomized, double-blind, placebo-controlled clinical trial.

Methods: A total of 50 females were included and randomized into two groups. The active group (n = 25) received two capsules totalling of Cynatine(®) HNS, comprised of Cynatine(®) brand keratin (500 mg) plus vitamins and minerals, per day, and the placebo group (n = 25) received two identical capsules of maltodextrin per day for 90 days. End points for skin moisture, skin elasticity, wrinkle reduction, skin compactness and skin appearance were measured.

Results: The results show that subjects taking Cynatine(®) HNS showed statistically significant improvements in their skin when compared with placebo.

Conclusion: Cynatine(®) HNS is an effective supplement for improving skin in 90 days or less.

Keywords: Cynatine® HNS; healthy skin; reduced wrinkles; skin elasticity; skin moisture.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Dietary Supplements / standards*
  • Double-Blind Method
  • Elasticity
  • Female
  • Humans
  • Italy
  • Keratins / administration & dosage*
  • Proteins / analysis
  • Skin / drug effects*
  • Skin / metabolism
  • Skin Aging / drug effects*
  • Skin Aging / physiology


  • Proteins
  • Keratins