Successful ABO-incompatible living-donor renal transplant without splenectomy for renal coloboma syndrome: a case report

Exp Clin Transplant. 2014 Apr;12(2):162-4. doi: 10.6002/ect.2013.0005. Epub 2013 Jul 30.


To our knowledge, this is the first report of an ABO-incompatible living-donor renal transplant without a splenectomy performed in a patient with renal coloboma syndrome, a rare disorder caused by PAX2 gene mutations, and that presents with renal and optic nerve hypodysplasia and disorders of the central nervous system. Many patients with renal coloboma syndrome develop end-stage renal disease requiring renal replacement therapy. Few reports of a well-defined course of renal transplant for coloboma syndrome have been published. We treated a 22-year-old man who had end-stage renal disease from renal coloboma syndrome. We performed an ABO-incompatible living-donor renal transplant with a kidney donated by his father. Two years after the transplant, the patient has good preserved renal function, and his compliance with the immunosuppressive regimen was good.

Publication types

  • Case Reports

MeSH terms

  • ABO Blood-Group System / immunology*
  • Blood Group Incompatibility / blood
  • Blood Group Incompatibility / complications
  • Blood Group Incompatibility / immunology*
  • Coloboma / complications
  • Coloboma / diagnosis
  • Coloboma / surgery*
  • Histocompatibility Testing
  • Histocompatibility*
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Kidney Failure, Chronic / diagnosis
  • Kidney Failure, Chronic / etiology
  • Kidney Failure, Chronic / surgery*
  • Kidney Transplantation / methods*
  • Living Donors*
  • Male
  • Renal Insufficiency / complications
  • Renal Insufficiency / diagnosis
  • Renal Insufficiency / surgery*
  • Splenectomy*
  • Treatment Outcome
  • Vesico-Ureteral Reflux / complications
  • Vesico-Ureteral Reflux / diagnosis
  • Vesico-Ureteral Reflux / surgery*
  • Young Adult


  • ABO Blood-Group System
  • Immunosuppressive Agents

Supplementary concepts

  • Papillorenal syndrome