Selecting a sample size for studies with repeated measures

BMC Med Res Methodol. 2013 Jul 31;13:100. doi: 10.1186/1471-2288-13-100.

Abstract

Many researchers favor repeated measures designs because they allow the detection of within-person change over time and typically have higher statistical power than cross-sectional designs. However, the plethora of inputs needed for repeated measures designs can make sample size selection, a critical step in designing a successful study, difficult. Using a dental pain study as a driving example, we provide guidance for selecting an appropriate sample size for testing a time by treatment interaction for studies with repeated measures. We describe how to (1) gather the required inputs for the sample size calculation, (2) choose appropriate software to perform the calculation, and (3) address practical considerations such as missing data, multiple aims, and continuous covariates.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural

MeSH terms

  • Analysis of Variance
  • Data Interpretation, Statistical
  • Humans
  • Models, Statistical*
  • Pain Measurement
  • Reproducibility of Results
  • Research Design
  • Sample Size*
  • Software