Intraarterial polidocanol injection for the treatment of peripheral arteriovenous malformations

Surg Today. 2014 Jul;44(7):1232-41. doi: 10.1007/s00595-013-0680-8. Epub 2013 Aug 2.

Abstract

Purpose: The purpose of this study was to investigate the efficacy and safety of intraarterial transcatheter administration of polidocanol as an alternative treatment for peripheral arteriovenous malformations (AVMs).

Methods: The study comprised 10 patients (six males and four females) with a mean age of 28.8 years (range 8-52 years). All patients had trunk or extremity AVMs. Following the administration of general anesthesia or intravenous (IV) sedation, the patients underwent staged intraarterial polidocanol sclerotherapy with or without additional embolizations for their AVMs. The administration of polidocanol was executed by intraarterial infusion through a microcatheter or by direct percutaneous entry into the nidus under ultrasound guidance.

Results: A total of 19 sessions were accomplished in 10 patients. Polidocanol was used alone in six of the 19 sessions. In 13 sessions, polidocanol was used in combination with another agent (including n-butyl cyanoacrylate (NBCA), lipiodol, and ethanol) and/or coils. In two sessions, polidocanol was administered percutaneously under ultrasound guidance directly into the nidus documented by arteriography. No major complications occurred.

Conclusion: Intraarterial transcatheter administration of polidocanol alone or in combination with other agents is a safe and effective alternative treatment for peripheral AVMs.

MeSH terms

  • Adolescent
  • Adult
  • Arteriovenous Malformations / therapy*
  • Bucrylate / administration & dosage
  • Child
  • Female
  • Humans
  • Injections, Intra-Arterial
  • Male
  • Middle Aged
  • Polidocanol
  • Polyethylene Glycols / administration & dosage*
  • Sclerotherapy / methods*
  • Tissue Adhesives / administration & dosage
  • Treatment Outcome
  • Young Adult

Substances

  • Tissue Adhesives
  • Polidocanol
  • Bucrylate
  • Polyethylene Glycols