Levels of selenium, zinc, copper, and cardiac troponin I in serum of patients with acute coronary syndrome

Biol Trace Elem Res. 2013 Sep;154(3):352-6. doi: 10.1007/s12011-013-9754-0. Epub 2013 Aug 1.


The aim of this study was to assess the levels of selenium (Se), zinc (Zn), copper (Cu), and troponin I (TnI) in patients with acute coronary syndrome (ACS) on admission to our emergency department in comparison to healthy control subjects. Patients with diagnosed ACS (n = 100) were included in the study group. Control subjects (n = 100) were selected from healthy volunteers in the same age range. Venous blood samples were obtained to evaluate the levels of Se, Zn, Cu, and TnI (on admission for the ACS group). Serum Se, Zn, and Cu levels were significantly less in the ACS group compared to the control group (p <0.001, p <0.01, and p <0.001, respectively). The serum TnI level was significantly greater in the ACS group compared to the control group (p <0.05). The serum Se level in the ACS group correlated significantly with the TnI level (r = -0.211, p = 0.035). These results indicate that Se, Zn, and Cu deficiencies may be risk factors for ACS, and a decreased serum Se level in patients with ACS might reflect the degree of myocardial necrosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Coronary Syndrome / blood*
  • Adult
  • Aged
  • Aged, 80 and over
  • Copper / blood*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Patient Admission
  • Risk Factors
  • Selenium / blood*
  • Troponin I / blood*
  • Zinc / blood*


  • Troponin I
  • Copper
  • Selenium
  • Zinc