Transmitting senescence to the cell neighbourhood

Nat Cell Biol. 2013 Aug;15(8):887-9. doi: 10.1038/ncb2811.


Senescence, a cell-autonomous tumour suppressor mechanism, also has pro-tumorigenic effects on neighbouring pre-malignant cells through the senescence-associated secretory phenotype (SASP). The SASP is now shown to be regulated by inflammasomes and to induce paracrine senescence in healthy cells, indicating that senescence may also represent a non-cell-autonomous tumour suppressor mechanism linked to innate immunity.

Publication types

  • News
  • Comment

MeSH terms

  • Animals
  • Cellular Senescence / physiology*
  • Humans
  • Inflammasomes / metabolism*


  • Inflammasomes