Kynurenate does not reduce infarct size after middle cerebral artery occlusion in spontaneously hypertensive rats

S Roussel; E Pinard; J Seylaz

doi:10.1016/0006-8993(90)90997-p

Kynurenate does not reduce infarct size after middle cerebral artery occlusion in spontaneously hypertensive rats

Brain Res. 1990 Jun 4;518(1-2):353-5. doi: 10.1016/0006-8993(90)90997-p.

Authors

S Roussel¹, E Pinard, J Seylaz

Affiliation

¹ Laboratoire de Physiologie et Physiopathologie cérébrovasculaire, U. 182 I.N.S.E.R.M., Paris, France.

PMID: 2390725
DOI: 10.1016/0006-8993(90)90997-p

Abstract

The effects of the excitatory amino acid receptor antagonist, kynurenate, were investigated in spontaneously hypertensive rats after middle cerebral artery occlusion. Kynurenate did not significantly modify either the infarct volume, measured 48 h after occlusion, or the neurological score. The absence of a neuroprotective effect of kynurenate in this study, which contrasts with results in normotensive rats, is suggested to be due to impaired collateral circulation in spontaneously hypertensive rats.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Caudate Nucleus / drug effects
Caudate Nucleus / pathology
Cerebral Arteries / physiology
Cerebral Cortex / drug effects
Cerebral Cortex / pathology
Cerebral Infarction / physiopathology*
Ischemic Attack, Transient / physiopathology*
Kynurenic Acid / pharmacology*
Male
Rats
Rats, Inbred SHR

Substances

Kynurenic Acid