Abstract
A new triterpenoid saponin, named cylindroside A (1), was isolated from the seeds of Cylindrokelupha dalatensis (Kosterm.) T.L. Wu by using chromatographic method. The structure of 1 was established by comprehensive spectroscopic analysis and chemical degradation. Compound 1 displayed significant antitumor activity in vitro against BCG and MCF-7 cancer cell lines and IC₅₀ values were 4.17 ± 0.23 and 3.07 ± 0.66 μM by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method, respectively.
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology*
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Drug Screening Assays, Antitumor
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Drugs, Chinese Herbal / chemistry*
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Humans
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Inhibitory Concentration 50
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MCF-7 Cells
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Saponins / chemistry
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Saponins / isolation & purification*
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Saponins / pharmacology*
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Seeds / chemistry
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Tetrazolium Salts
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Thiazoles
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Triterpenes / chemistry
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Triterpenes / isolation & purification*
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Triterpenes / pharmacology*
Substances
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Antineoplastic Agents, Phytogenic
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Drugs, Chinese Herbal
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Saponins
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Tetrazolium Salts
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Thiazoles
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Triterpenes
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cylindroside A
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thiazolyl blue