Genetic and epigenetic variations in iPSCs: potential causes and implications for application

Cell Stem Cell. 2013 Aug 1;13(2):149-59. doi: 10.1016/j.stem.2013.07.001.


The ability to reprogram somatic cells to induced pluripotent stem cells (iPSCs) has revolutionized the field of regenerative medicine. However, recent studies on the genetic and epigenetic variations in iPSCs have raised concerns that these variations may compromise the utility of iPSCs. In this Perspective, we review the current understanding of genetic and epigenetic variations in iPSCs, trace their causes, discuss the implications of these variations for iPSC applications, and propose approaches to cope with these variations.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Epigenesis, Genetic*
  • Genetic Variation
  • Humans
  • Induced Pluripotent Stem Cells / metabolism*
  • Stem Cell Transplantation*