Effect of implantation of biodegradable magnesium alloy on BMP-2 expression in bone of ovariectomized osteoporosis rats

Mater Sci Eng C Mater Biol Appl. 2013 Oct;33(7):4470-4. doi: 10.1016/j.msec.2013.05.042. Epub 2013 May 24.

Abstract

The study was focused on the implantation of a biodegradable AZ31 magnesium alloy into the femoral periosteal of the osteoporosis modeled rats. The experimental results showed that after 4weeks implantation of AZ31 alloy in the osteoporosis modeled rats, the expression of BMP-2 in bone tissues of the rats was much enhanced, even higher than the control group, which should promote the bone formation and be beneficial for reducing the harmful effect of osteoporosis. Results of HE stains showed that the implantation of AZ31 alloy did not have obvious pathological changes on both the liver and kidney of the animal.

Keywords: BMP-2; Magnesium alloy; Osteoblast; Osteoporosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alloys / pharmacology*
  • Animals
  • Biodegradation, Environmental / drug effects
  • Biopsy
  • Bone Morphogenetic Protein 2 / metabolism*
  • Bone and Bones / drug effects
  • Bone and Bones / metabolism*
  • Bone and Bones / pathology
  • Female
  • Immunohistochemistry
  • Kidney / drug effects
  • Kidney / pathology
  • Liver / drug effects
  • Liver / pathology
  • Osteoblasts / drug effects
  • Osteoblasts / pathology
  • Osteoporosis / metabolism*
  • Ovariectomy
  • Prosthesis Implantation*
  • Rats
  • Rats, Sprague-Dawley
  • Staining and Labeling

Substances

  • Alloys
  • Bone Morphogenetic Protein 2
  • Mg-Al-Zn-Mn-Si-Cu alloy