The efficacy of periarticular multimodal drug injection for postoperative pain management in total knee or hip arthroplasty

J Arthroplasty. 2013 Dec;28(10):1882-7. doi: 10.1016/j.arth.2013.06.031. Epub 2013 Aug 1.


The efficacy of periarticular multimodal drug injection (PMDI) to reduce pain after total knee or hip arthroplasty (TKA or THA) still remains controversial. Our study aimed at evaluating the efficacy of PMDI after TKA or THA. A fully recursive literature search was conducted to identify relevant randomized controlled trials. Ultimately, 21 studies were included in the analysis. Pooled results showed that the PMDI group had better pain relief, less opioid consumption, larger range of motion, and lower rates of nausea and vomiting than the placebo group. No significant difference was seen in regard to the length of hospital stay between the two groups. In conclusion, PMDI should be recommended for the pain management after TKA or THA.

Keywords: hip arthroplasty; knee arthroplasty; periarticular multimodal drug injection.

Publication types

  • Meta-Analysis
  • Review

MeSH terms

  • Analgesics / administration & dosage*
  • Arthroplasty, Replacement, Hip*
  • Arthroplasty, Replacement, Knee*
  • Humans
  • Injections
  • Injections, Intra-Articular
  • Pain, Postoperative / drug therapy*
  • Randomized Controlled Trials as Topic
  • Treatment Outcome


  • Analgesics