Association of the FTO and ADRB2 genes with body composition and fat distribution in obese women

Maturitas. 2013 Oct;76(2):165-71. doi: 10.1016/j.maturitas.2013.07.004. Epub 2013 Aug 1.


Objective: The aim of this study was to investigate whether the polymorphisms of the fat mass and obesity-associated gene (FTO, rs9939609:T>A) and the β2-adrenergic receptor gene (ADRB2, rs1042714:Gln>Glu) are associated with weight loss in dieting obese premenopausal women and the association of these SNPs with body weight, body composition and distribution of fat mass.

Methods: 75 obese (BMI>30) premenopausal women participated in the intervention including a 3-month weight reduction period and a subsequent 9-month weight maintenance period. Weight and height were measured and BMI calculated. Body composition and fat mass distribution were assessed by dual energy X-ray absorptiometry.

Results: At baseline, the AA homozygotes of the FTO gene were 10.1 kg heavier (p=0.031), they had higher BMI (p=0.038), and greater waist and greater hip circumference (p=0.08 and p=0.067, respectively) compared to the TT homozygotes. Gln/Gln carriers of the ADRB2 gene had smaller gynoid fat-% compared with both the Gln/Glu and Glu/Glu carriers (p=0.050 and p=0.009, respectively). The Gln homozygotes had also smaller total body fat-% and higher total body lean mass-% than that of the Glu homozygotes (p=0.018 and p=0.019, respectively).

Conclusion: FTO genotype was associated with body weight in general, whereas ADRB2 genotype was associated with fat distribution. However, all women in the study group lost weight similarly independently of their genotypes. Neither the FTO nor ADRB2 genotype had statistically significant effect on weight reduction or weight maintenance.

Keywords: A; ADRB2; BMI; DXA; FTO; GLM; Genetic variants; Gln; Glu; Obesity; SNP; T; VLED; Weight maintenance; Weight reduction; adenine; body mass index; dual-energy X-ray absorptiometry; fat mass and obesity-associated gene; general linear model; glutamic acid; glutamine; single nucleotide polymorphism; thymine; very-low-energy diet; β2-adrenergic receptor gene.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alpha-Ketoglutarate-Dependent Dioxygenase FTO
  • Body Composition / genetics
  • Body Composition / physiology
  • Body Mass Index
  • DNA / chemistry
  • DNA / genetics
  • Female
  • Genotype
  • Humans
  • Middle Aged
  • Obesity / genetics*
  • Obesity / metabolism
  • Polymerase Chain Reaction
  • Polymorphism, Single Nucleotide
  • Proteins / genetics*
  • Proteins / physiology
  • Receptors, Adrenergic, beta-2 / genetics*
  • Receptors, Adrenergic, beta-2 / metabolism
  • Weight Loss / genetics
  • Weight Loss / physiology


  • ADRB2 protein, human
  • Proteins
  • Receptors, Adrenergic, beta-2
  • DNA
  • Alpha-Ketoglutarate-Dependent Dioxygenase FTO
  • FTO protein, human