Renal artery fibromuscular dysplasia in 2,640 renal donor subjects: a CT angiography analysis

J Vasc Interv Radiol. 2013 Oct;24(10):1477-80. doi: 10.1016/j.jvir.2013.06.006. Epub 2013 Aug 2.


Purpose: To present the incidence, demographics, and clinical presentation of patients diagnosed with renal fibromuscular dysplasia (FMD) who underwent computed tomography (CT) angiography for evaluation of living renal donor protocol.

Methods and materials: A retrospective review was performed from January 1, 2000, to December 31, 2011 on patients who underwent CT angiography for evaluation of living renal donor protocol. Of 2,640 patients identified, only patients with a diagnosis of FMD by the radiology report underwent independent reader evaluation of CT angiography for the presence of FMD and associated characteristics. The demographics, medical history, and presentation were reviewed using the electronic medical chart.

Results: The independent readers who evaluated CT angiography identified a diagnosis of FMD in 68 patients (2.6%; 59 female) with an average age of 52 years ± 10. Unilateral FMD was observed in 46 patients (68%), and bilateral FMD was observed in 22 patients (32%). Three patients had aneurysms of the renal artery. Comorbidities included hypertension (n = 21, 31%), dyslipidemia, (n = 13, 19%), history of migraines (n = 3, 4%), and history of smoking (n = 14, 21%). No patients had diabetes mellitus, coronary artery disease, or family history of FMD. Of 21 patients (31%) with a history of hypertension, 13 patients (62%) were treated with antihypertensive medications.

Conclusions: The incidence of FMD in patients who underwent CT angiography for evaluation of living renal donor protocol is 2.6%.

Keywords: DSA; FMD; digital subtraction angiography; fibromuscular dysplasia.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Age Distribution
  • Angiography / statistics & numerical data*
  • Comorbidity
  • Female
  • Fibromuscular Dysplasia / diagnostic imaging*
  • Fibromuscular Dysplasia / epidemiology*
  • Humans
  • Incidence
  • Kidney Transplantation / statistics & numerical data*
  • Living Donors / statistics & numerical data*
  • Male
  • Middle Aged
  • Minnesota / epidemiology
  • Postoperative Complications / diagnostic imaging*
  • Postoperative Complications / epidemiology
  • Reproducibility of Results
  • Retrospective Studies
  • Risk Factors
  • Sensitivity and Specificity
  • Sex Distribution
  • Tomography, X-Ray Computed / statistics & numerical data*
  • Treatment Outcome