Degradation of human cartilage by monocytes

L M Kumaratilake; I C Kowanko; E J Bates; A Ferrante

doi:10.1016/0165-2478(90)90006-c

Degradation of human cartilage by monocytes

Immunol Lett. 1990 Jul;24(4):243-5. doi: 10.1016/0165-2478(90)90006-c.

Authors

L M Kumaratilake¹, I C Kowanko, E J Bates, A Ferrante

Affiliation

¹ Department of Immunology, Adelaide Children's Hospital, North Adelaide, South Australia.

PMID: 2391132
DOI: 10.1016/0165-2478(90)90006-c

Abstract

The effect of human peripheral blood monocytes on the degradation of human articular cartilage was studied in vitro using a radiometric assay to detect proteoglycan breakdown. The results showed that proteoglycan breakdown was increased by 60% after a 20 h exposure to monocytes (p less than 0.001).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cartilage, Articular / metabolism*
Humans
In Vitro Techniques
Monocytes / metabolism*
Proteoglycans / metabolism

Substances

Proteoglycans