Antibody-drug conjugate target selection: critical factors

Methods Mol Biol. 2013:1045:29-40. doi: 10.1007/978-1-62703-541-5_2.

Abstract

ADC success requires that all three components of the agent function in a near-flawless manner. Equally important is that the target be selected with stringent consideration as the target is the one factor in ADC development that is immutable and beyond the reach of the developer to refine/manipulate. This chapter reviews the critical factors of target selection that must be met if one is to succeed at ADC development.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigens, Surface / immunology
  • Drug Discovery / methods*
  • Glutamate Carboxypeptidase II / immunology
  • Humans
  • Immunoconjugates / immunology*
  • Immunoconjugates / metabolism
  • Immunoconjugates / therapeutic use
  • Pharmaceutical Preparations / chemistry*

Substances

  • Antigens, Surface
  • Immunoconjugates
  • Pharmaceutical Preparations
  • FOLH1 protein, human
  • Glutamate Carboxypeptidase II