Antibody-drug conjugate payloads

Methods Mol Biol. 2013:1045:51-70. doi: 10.1007/978-1-62703-541-5_4.


Toxin payloads, or drugs, are the crucial components of therapeutic antibody-drug conjugates (ADCs). This review will give an introduction on the requirements that make a toxic compound suitable to be used in an antitumoral ADC and will summarize the structural and mechanistic features of four drug families that yielded promising results in preclinical and clinical studies.

Publication types

  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Humans
  • Immunoconjugates / chemistry
  • Immunoconjugates / pharmacology*
  • Pharmaceutical Preparations / chemistry*


  • Antineoplastic Agents
  • Immunoconjugates
  • Pharmaceutical Preparations