Aging and chronic kidney disease: the impact on physical function and cognition

J Gerontol A Biol Sci Med Sci. 2014 Mar;69(3):315-22. doi: 10.1093/gerona/glt109. Epub 2013 Aug 2.


Evidence has recently been building that the presence of chronic kidney disease (CKD) is an independent contributor to decline in physical and cognitive functions in older adults. CKD affects 45% of persons older than 70 years of age and can double the risk for physical impairment, cognitive dysfunction, and frailty. To increase awareness of this relatively new concept of CKD as a risk factor for accelerated aging, we review studies on the association of CKD with physical function, frailty, and cognitive function. We also present a summary of the proposed mechanisms for these associations.

Keywords: Chronic kidney disease; Cognitive function.; Frailty; Physical function.

Publication types

  • Review

MeSH terms

  • Aging / physiology*
  • Cognition / physiology*
  • Cognition Disorders / etiology
  • Disabled Persons
  • Humans
  • Motor Activity / physiology*
  • Renal Insufficiency, Chronic / physiopathology*