Hypertrophic scars are abnormal scars that develop after wound-healing, especially in some ethnic backgrounds. The after-effects of these scars result in depression, posttraumatic stress syndrome, anxiety, impaired self-esteem and quality of life. Treatment of these scars still is a subject of different studies and is a challenging issue in reconstructive medicine. We reviewed the current published articles about the effects of vitamin E on scar formation and its clinical effectiveness. The application of vitamin E is popular interest, but it still needs more clinical studies to establish its perceived outcomes.