The use of salivary protein secretions as an in vivo model to study Mantel cell lymphoma progression and treatment

Cancer Invest. 2013 Aug;31(7):494-9. doi: 10.3109/07357907.2013.820319.

Abstract

Purpose: The objective of this study was to compare the salivary protein profiles from an individual diagnosed with MCL before, during, and after chemotherapy.

Methods: Saliva specimens acquire prior, during, and after chemotherapy. Specimens were analyzed using a LC-MS/MS mass spectrometer.

Results: The results of the study suggest salivary protein alterations secondary to MCL and that a number of the proteins were changed as a result of chemotherapeutic intervention suggesting that the treatment, from a proteomic perspective, was efficacious. The study suggests that salivary secretions may be used as in vivo model for studying MCL progression and treatment efficacy.

Publication types

  • Case Reports

MeSH terms

  • Aged, 80 and over
  • Antineoplastic Combined Chemotherapy Protocols
  • Disease Progression
  • Electrophoresis, Gel, Two-Dimensional
  • Humans
  • Lymphoma, Mantle-Cell / drug therapy
  • Lymphoma, Mantle-Cell / metabolism*
  • Lymphoma, Mantle-Cell / pathology
  • Male
  • Proteomics / methods*
  • Saliva / chemistry*
  • Salivary Proteins and Peptides / analysis*

Substances

  • Salivary Proteins and Peptides