Genetics of ankylosing spondylitis

Mol Immunol. 2014 Jan;57(1):2-11. doi: 10.1016/j.molimm.2013.06.013. Epub 2013 Jul 31.


Ankylosing spondylitis (AS) is a chronic inflammatory arthritis that affects the spine and sacroiliac joints. It causes significant disability and is associated with a number of other features including peripheral arthritis, anterior uveitis, psoriasis and inflammatory bowel disease (IBD). Significant progress has been made in the genetics of AS have in the last five years, leading to new treatments in trial, and major leaps in understanding of the aetiopathogenesis of the disease.

Keywords: Ankylosing spondylitis; Single nucleotide polymorphism association; Spondyloarthritis.

Publication types

  • Review

MeSH terms

  • Aminopeptidases / genetics
  • Genetic Predisposition to Disease
  • HLA-B27 Antigen / genetics*
  • HLA-B27 Antigen / immunology
  • Humans
  • Inflammatory Bowel Diseases / complications
  • Interleukin-23 / genetics
  • Major Histocompatibility Complex / genetics
  • Minor Histocompatibility Antigens
  • Psoriasis / complications
  • Sacroiliac Joint / pathology
  • Spine / pathology
  • Spondylitis, Ankylosing / genetics*
  • Spondylitis, Ankylosing / pathology*
  • Uveitis, Anterior / complications


  • HLA-B27 Antigen
  • Interleukin-23
  • Minor Histocompatibility Antigens
  • Aminopeptidases
  • ERAP1 protein, human