Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 25 (12), 2335-47

IL-17 Family Cytokines Mediated Signaling in the Pathogenesis of Inflammatory Diseases

Affiliations
Review

IL-17 Family Cytokines Mediated Signaling in the Pathogenesis of Inflammatory Diseases

Xinyang Song et al. Cell Signal.

Abstract

Inflammation is the immediate protective response of the body to pathogen invasions, allergen challenges, chemical exposures or physical injuries. Acute inflammation usually accompanies with transient infiltration of leukocytes, removal of danger signals and eventually tissue repair, while persistent and uncontrolled inflammation becomes a major stimulator in the progression of many chronic diseases in human, including autoimmune diseases, metabolic disorders and cancer. Interleukin (IL)-17 family is a recent classified subset of cytokines, playing critical roles in both acute and chronic inflammatory responses. In this review, we will summarize recent progresses on the signalings of this family cytokines and their impacts on the inflammatory responses or disorders.

Keywords: IL-17 family cytokines; Inflammation; Signal transduction.

Similar articles

See all similar articles

Cited by 33 PubMed Central articles

See all "Cited by" articles

Publication types

LinkOut - more resources

Feedback