Facets of small RNA-mediated regulation in Legionella pneumophila

Curr Top Microbiol Immunol. 2013;376:53-80. doi: 10.1007/82_2013_347.

Abstract

Legionella pneumophila is a water-borne pathogen that causes a severe lung infection in humans. It is able to replicate inside amoeba in the water environment, and inside lung macrophages in humans. Efficient regulation of gene expression is critical for responding to the conditions that L. pneumophila encounters and for intracellular multiplication in host cells. In the last two decades, many reports have contributed to our understanding of the critical importance of small regulatory RNAs (sRNAs) in the regulatory network of bacterial species. This report presents the current state of knowledge about the sRNAs expressed by L. pneumophila and discusses a few regulatory pathways in which sRNAs should be involved in this pathogen.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Bacterial Proteins / physiology
  • Gene Expression Regulation, Bacterial
  • Host Factor 1 Protein / physiology
  • Iron / metabolism
  • Legionella pneumophila / genetics*
  • Oxidative Stress
  • RNA, Small Untranslated / physiology*
  • Sigma Factor / physiology

Substances

  • Bacterial Proteins
  • Host Factor 1 Protein
  • RNA, Small Untranslated
  • Sigma Factor
  • sigma factor KatF protein, Bacteria
  • Iron