Neuroimaging of the Philadelphia neurodevelopmental cohort

Neuroimage. 2014 Feb 1;86:544-53. doi: 10.1016/j.neuroimage.2013.07.064. Epub 2013 Aug 3.


The Philadelphia Neurodevelopmental Cohort (PNC) is a large-scale, NIMH funded initiative to understand how brain maturation mediates cognitive development and vulnerability to psychiatric illness, and understand how genetics impacts this process. As part of this study, 1445 adolescents ages 8-21 at enrollment underwent multimodal neuroimaging. Here, we highlight the conceptual basis for the effort, the study design, and the measures available in the dataset. We focus on neuroimaging measures obtained, including T1-weighted structural neuroimaging, diffusion tensor imaging, perfusion neuroimaging using arterial spin labeling, functional imaging tasks of working memory and emotion identification, and resting state imaging of functional connectivity. Furthermore, we provide characteristics regarding the final sample acquired. Finally, we describe mechanisms in place for data sharing that will allow the PNC to become a freely available public resource to advance our understanding of normal and pathological brain development.

Keywords: Adolescence; Brain; Connectome; Development; MRI; Neuroimaging; Resting-state; fMRI.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adolescent
  • Adult
  • Brain / physiology*
  • Child
  • Cognition / physiology*
  • Cohort Studies
  • Female
  • Humans
  • Multimodal Imaging / methods*
  • Neuroimaging / methods*
  • Philadelphia
  • Research Design*
  • Young Adult