Based on grey entropy analysis, the relational grade of operational parameters with aerobic granular sludge's granulation indicators was studied. The former consisted of settling time (ST), aeration time (AT), superficial gas velocity (SGV), height/diameter (H/D) ratio and organic loading rates (OLR), the latter included sludge volume index (SVI) and set-up time. The calculated result showed that for SVI and set-up time, the influence orders and the corresponding grey entropy relational grades (GERG) were: SGV (0.9935) > AT (0.9921) > OLR (0.9894) > ST (0.9876) > H/D (0.9857) and SGV (0.9928) > H/D (0.9914) > AT (0.9909) > OLR (0.9897) > ST (0.9878). The chosen parameters were all key impact factors as each GERG was larger than 0.98. SGV played an important role in improving SVI transformation and facilitating the set-up process. The influence of ST on SVI and set-up time was relatively low due to its dual functions. SVI transformation and rapid set-up demanded different optimal H/D ratio scopes (10-20 and 16-20). Meanwhile, different functions could be obtained through adjusting certain factors' scope.