Effects of a hot-water extract of porcini (Boletus aestivalis) mushrooms on the blood pressure and heart rate of spontaneously hypertensive rats

Biosci Biotechnol Biochem. 2013;77(8):1769-72. doi: 10.1271/bbb.130085. Epub 2013 Aug 7.


The repeated once-daily oral administration of a hot-water extract of porcini, Boletus aestivalis, mushrooms (WEP) to spontaneously hypertensive rats (SHR) for 18 weeks decreased the systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate. The WEP administration also decreased blood urea nitrogen (BUN), creatinine (Cre), and triglyceride (TG), and increased high-density lipoprotein-cholesterol (HDL-C) in the blood, suggesting that WEP improved the status of hypertension, as well as the high heart rate and metabolic abnormalities involved in hypertension.

MeSH terms

  • Agaricales / chemistry
  • Animals
  • Antihypertensive Agents / administration & dosage*
  • Antihypertensive Agents / chemistry
  • Basidiomycota / chemistry
  • Blood Pressure / drug effects*
  • Heart Rate / drug effects*
  • Humans
  • Hypertension / drug therapy*
  • Hypertension / pathology
  • Plant Extracts / administration & dosage
  • Plant Extracts / chemistry
  • Rats
  • Water


  • Antihypertensive Agents
  • Plant Extracts
  • Water