Review of current indications for combined very high fluence collagen cross-linking and laser in situ keratomileusis surgery

Indian J Ophthalmol. 2013 Aug;61(8):430-2. doi: 10.4103/0301-4738.116074.


In this brief review we will discuss the reasoning and evolution of our current use of combined very high-fluence collagen crosslinking and laser in situ keratomileusis. Several presentations and pertinent publications are reviewed, along with the key steps of the enhanced LASIK procedure. Long term outcome data support the safety and efficacy of LASIK Xtra in stabilizing myopic but also hyperopic LASIK results.In conclusion, we have compelling evidence that LASIK Xtra is a safe and effective adjunct.

Publication types

  • Review

MeSH terms

  • Collagen / metabolism*
  • Combined Modality Therapy
  • Corneal Stroma / metabolism*
  • Cross-Linking Reagents / therapeutic use*
  • Humans
  • Keratoconus / drug therapy
  • Keratoconus / metabolism
  • Keratoconus / surgery
  • Keratoconus / therapy*
  • Keratomileusis, Laser In Situ / methods*
  • Photochemotherapy / methods
  • Photosensitizing Agents / therapeutic use*
  • Riboflavin / therapeutic use
  • Ultraviolet Rays


  • Cross-Linking Reagents
  • Photosensitizing Agents
  • Collagen
  • Riboflavin