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. 1990 Aug 24;249(4971):908-12.
doi: 10.1126/science.2392681.

Increased Life-Span of age-1 Mutants in Caenorhabditis Elegans and Lower Gompertz Rate of Aging

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Increased Life-Span of age-1 Mutants in Caenorhabditis Elegans and Lower Gompertz Rate of Aging

T E Johnson. Science. .

Abstract

A mutation in the age-1 gene of the nematode Caenorhabditis elegans has been shown to result in a 65 percent increase in mean life-span and a 110 percent increase in maximum life-span at 25 degrees. One of the hallmarks of organismic aging and senescent processes is an exponential acceleration of age-specific mortality rate with chronological age. This exponential acceleration is under genetic control: age-1 mutant hermaphrodites show a 50 percent slower rate of acceleration of mortality with chronological age than wild-type strains. Mutant males also show a lengthening of life and a slowing of the rate of acceleration of mortality, although age-1 mutant males still have significantly shorter life-spans than do hermaphrodites of the same genotype. The slower rates of acceleration of mortality are recessive characteristics of the age-1 mutant alleles examined.

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