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. 2013 Dec;51(4):264-70.
doi: 10.1016/j.bcmd.2013.07.005. Epub 2013 Aug 6.

Notch and Wnt Signaling in the Emergence of Hematopoietic Stem Cells


Notch and Wnt Signaling in the Emergence of Hematopoietic Stem Cells

Anna Bigas et al. Blood Cells Mol Dis. .


Hematopoietic stem cells (HSC), which reside in the marrow of adult mammals and sustain hematopoiesis for the lifetime of the organism, are specified and generated during embryonic development. We are just beginning to understand how HSC develop from more primitive cells and the complexity of the signaling pathways involved. In this work, we review the role of two crucial pathways, Notch and Wnt, in the specification and development of HSC and their nascent microenvironment, the arterial vessels.

Keywords: AGM; Delta-like ligand; Dll; EGF; Embryonic hematopoiesis; FL; Frizzled; Fzd; GOF; HSC; Hematopoiesis; Hes; Hrt; Jag; Jagged ligand; LDL-receptor related proteins; LEF/TCF; LOF; LRP; NICD; Notch; Notch intracellular domain; PB; RBPj; Wnt; YS; aorta-gonad-mesonephros; epidermal growth factor; fetal liver; gain of function; hairy/enhancer-of-split; hairy/enhancer-of-split related transcriptional factor; hematopoietic stem cell; loss of function; lymphoid enhancer factor T-cell factor; peripheral blood; recombination signal binding protein for immunoglobulin kappa J region; yolk sac.

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