Lineage specification: reading the instructions may help!

Curr Biol. 2013 Aug 5;23(15):R662-5. doi: 10.1016/j.cub.2013.06.054.


Understanding lineage specification is biologically important and critical for the production of cells for regenerative medicine. Extrinsic cues are clearly necessary but do they direct or select lineage? Single-cell analysis now suggests that cytokine signaling can instruct lineage choice in blood stem cells.

Publication types

  • Comment

MeSH terms

  • Animals
  • Cell Differentiation / drug effects*
  • Cell Lineage / drug effects*
  • Hematopoietic Stem Cells / cytology*
  • Hematopoietic Stem Cells / drug effects*
  • Macrophage Colony-Stimulating Factor / pharmacology*
  • Myeloid Cells / cytology*
  • Myeloid Cells / drug effects*


  • Macrophage Colony-Stimulating Factor