1H magnetic resonance spectroscopy in multiple sclerosis and related disorders

Neuroimaging Clin N Am. 2013 Aug;23(3):459-74. doi: 10.1016/j.nic.2013.03.005. Epub 2013 May 10.


Proton magnetic resonance spectroscopy ((1)H-MRS) is an unconventional technique that allows noninvasive characterization of metabolic abnormalities in the central nervous system. (1)H-MRS provides important insights into the chemical-pathologic changes that occur in patients with multiple sclerosis (MS). In this review article we present the main brain and spinal cord (1)H-MRS features in MS, their diagnostic value in differentiating pseudotumoral demyelinating lesions from primary brain tumors, and their relationship with clinical variables. Last, some data related to the use of (1)H-MRS in therapeutic trials is presented.

Keywords: Brain; Diagnosis; Magnetic resonance spectroscopy; Multiple sclerosis; Spinal cord.

Publication types

  • Review

MeSH terms

  • Aspartic Acid / analogs & derivatives*
  • Aspartic Acid / metabolism
  • Biomarkers / metabolism
  • Brain / metabolism*
  • Humans
  • Magnetic Resonance Spectroscopy / methods*
  • Multiple Sclerosis / diagnosis*
  • Multiple Sclerosis / metabolism*
  • Protons*


  • Biomarkers
  • Protons
  • Aspartic Acid
  • N-acetylaspartate