Randomised clinical efficacy trial of potassium oxalate mouthrinse in relieving dentinal sensitivity

J Dent. 2013 Jul;41 Suppl 4:S40-8. doi: 10.1016/S0300-5712(13)70005-8.

Abstract

Objective: The study aimed to determine the efficacy in relieving dentinal sensitivity of 4 weeks' treatment with an alcohol-free mouthrinse comprising 1.4% potassium oxalate (KO) (Listerine® Advanced Defence Sensitive; LADS), compared with negative and positive controls.

Methods: Subjects were randomised to one of three treatments: LADS mouthrinse - twice-daily toothbrushing with Crest® Cavity Protection Regular toothpaste, rinsing with water and then 10 mL LADS mouthrinse, followed by expectoration; negative control (twice-daily brushing with Crest Cavity Protection Regular toothpaste); or positive control (twice-daily brushing with Sensodyne® Original desensitising toothpaste). Dentine sensitivity was assessed at baseline and after 2 and 4 weeks by Yeaple probe (tactile pressure; patient-reported discomfort by visual analogue scale [VAS]), air blast (VAS) and global subjective sensitivity (VAS). Oral tolerance was monitored throughout the study.

Results: At 2 weeks, subjects treated with the positive control and LADS mouthrinse showed significant reductions (p<0.05) in sensitivity scores versus the negative control. At 4 weeks, sensitivity decreased by 110% in the positive-control subjects versus negative-control subjects (p<0.001); sensitivity decreased by 80% in subjects receiving LADS mouthrinse versus negative-control subjects (p<0.05). No serious treatment-related oral adverse events were reported.

Conclusions: The positive control (Sensodyne Original) significantly reduced sensitivity compared with the negative control (Crest toothpaste alone), thus validating the study. The LADS mouthrinse (1.4% KO mouthrinse) significantly reduced sensitivity compared with the negative control, suggesting that LADS mouthrinse was responsible for the clinical effect observed. The treatments were well tolerated.

Clinical significance: To our knowledge, this is the first randomised clinical study to demonstrate the efficacy of a KO-containing mouthrinse (LADS) in relieving dentinal sensitivity.

Trial registration: ClinicalTrials.gov NCT01345292.

Keywords: Air blast; Dentine sensitivity; Efficacy; Mouthrinse; Potassium oxalate; Tactile.

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Air
  • Dentin Desensitizing Agents / therapeutic use*
  • Dentin Sensitivity / diagnosis
  • Dentin Sensitivity / drug therapy*
  • Drug Combinations
  • Female
  • Fluorides / therapeutic use
  • Follow-Up Studies
  • Humans
  • Male
  • Mouthwashes / therapeutic use*
  • Nitrates / therapeutic use
  • Oxalic Acid / therapeutic use*
  • Pain Measurement
  • Phosphates / therapeutic use
  • Potassium Compounds / therapeutic use
  • Silicic Acid / therapeutic use
  • Single-Blind Method
  • Sodium Fluoride / therapeutic use
  • Toothpastes / therapeutic use
  • Touch / physiology
  • Treatment Outcome
  • Visual Analog Scale

Substances

  • Dentin Desensitizing Agents
  • Drug Combinations
  • Mouthwashes
  • Nitrates
  • Phosphates
  • Potassium Compounds
  • Sensodyne
  • Toothpastes
  • hydrated silica gel-based toothpaste
  • Silicic Acid
  • Sodium Fluoride
  • Oxalic Acid
  • Fluorides
  • potassium nitrate

Associated data

  • ClinicalTrials.gov/NCT01345292