Thalidomide-a Notorious Sedative to a Wonder Anticancer Drug

Curr Med Chem. 2013;20(33):4102-8. doi: 10.2174/09298673113209990198.

Abstract

In the past 50 years, thalidomide has undergone a remarkable metamorphosis from a notorious drug inducing birth defects into a highly effective therapy for treating leprosy and multiple myeloma. Today, most notably, thalidomide and its analogs have shown efficacy against a wide variety of diseases, including inflammation and cancer. The mechanism underlying its teratogenicity as well as its anticancer activities has been intensively studied. This review summarizes the biological effects and therapeutic uses of thalidomide and its analogs, and the underlying mechanisms of thalidomide's action with a focus on its suppression of tumor growth.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology
  • Antineoplastic Agents / therapeutic use*
  • Cell Adhesion / drug effects
  • Cytokines / metabolism
  • Humans
  • Neoplasms / drug therapy*
  • Neoplasms / metabolism
  • Neoplasms / pathology
  • Neovascularization, Physiologic / drug effects
  • Thalidomide / analogs & derivatives
  • Thalidomide / pharmacology
  • Thalidomide / therapeutic use*

Substances

  • Antineoplastic Agents
  • Cytokines
  • Thalidomide