Lanthanum-induced neurotoxicity: solving the riddle of its involvement in cognitive impairment?

Arch Toxicol. 2013 Nov;87(11):2031-2035. doi: 10.1007/s00204-013-1112-7. Epub 2013 Aug 10.


The conclusion of a series of recent reports highlights the significant neurotoxic effects that rare earth elements, such as lanthanum (La), can have during neurodevelopment. These findings are, herein, combined and presented using a simplified schematic overview that provides a putative solution to the riddle of La-induced cognitive impairment. Our commentary also highlights potential targets for further investigations into the mechanisms which underpin La-induced neurotoxicity, with a focus on the crucial role of the hippocampus. Within this context, a central role for the cyclic-adenosine monophosphate signalling pathway is proposed.

Publication types

  • Letter
  • Comment

MeSH terms

  • Animals
  • Lanthanum / toxicity*
  • Maze Learning / drug effects*
  • Memory Disorders / chemically induced*
  • NF-kappa B / metabolism*


  • NF-kappa B
  • Lanthanum