A comparison of pregnancy rate before and after the administration of HCG in intrauterine insemination

Arch Gynecol Obstet. 2014 Feb;289(2):429-32. doi: 10.1007/s00404-013-2981-y. Epub 2013 Aug 10.


Purpose: Intrauterine insemination (IUI) is one of the first treatments of infertility. In natural cycles, women conceive when an intercourse takes place during a 6-day period ending on the day of ovulation. The current practice in IUI cycles is to perform IUI 24-36 h after the HCG administration, when the ovulation already took place. In this study, HCG was administered after IUI, which more closely resembles the fertilization process in natural cycles. The aim of the present study is to compare the fertility rates in an IUI protocol in women who took an HCG injection before and after the IUI.

Methods: This study was conducted on 100 infertile couples who referred to the infertility research center of Shahid Sadoughi University of Medical Sciences. They were divided into two groups: HCG injection before IUI and HCG injection after IUI. The main outcome measure was the result of a β HCG test that was done two weeks after the IUI; if it was positive, transvaginal sonography would be performed in the seventh week for clinical confirmation of pregnancy.

Results: The analysis included 50 cycles with HCG administered before and 50 cycles with HCG administered after the IUI. The pregnancy rates were 10 and 12 % (P = 0.85), respectively. Independent factor affected the cycle outcome was the time of infertility.

Conclusion: HCG administration after IUI brought about no improvement in the pregnancy rate. Therefore, HCG can be administered either before or after IUI.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Chorionic Gonadotropin, beta Subunit, Human / administration & dosage*
  • Female
  • Humans
  • Infertility, Female / therapy*
  • Insemination, Artificial / methods*
  • Male
  • Ovulation Induction / methods*
  • Pregnancy
  • Pregnancy Rate*
  • Time Factors


  • Chorionic Gonadotropin, beta Subunit, Human