Effects of ellagitannin-rich berries on blood lipids, gut microbiota, and urolithin production in human subjects with symptoms of metabolic syndrome

Mol Nutr Food Res. 2013 Dec;57(12):2258-63. doi: 10.1002/mnfr.201300280. Epub 2013 Aug 12.


Ellagitannins are polyphenols abundant in strawberries, raspberries, and cloudberries. The effects of a mixture of these berries were studied in a randomized controlled trial with subjects having symptoms of metabolic syndrome. The study focused on serum lipid profiles, gut microbiota, and ellagitannin metabolites. The results indicate that bioavailability of ellagitannins appears to be dependent on the composition of gut microbiota.

Trial registration: ClinicalTrials.gov NCT01414647.

Keywords: Clinical trial; Ellagitannin-rich berries; Lipidomics; Microbiological profiling; Urolithins.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Blood Pressure / drug effects
  • Coumarins / urine
  • Fruit / chemistry*
  • Gastrointestinal Tract / drug effects
  • Gastrointestinal Tract / microbiology*
  • Humans
  • Hydrolyzable Tannins / pharmacology*
  • Hydrolyzable Tannins / urine
  • Lipids / blood*
  • Metabolic Syndrome / diet therapy*
  • Metabolic Syndrome / metabolism*
  • Metabolic Syndrome / microbiology
  • Microbiota
  • Treatment Outcome


  • Coumarins
  • Hydrolyzable Tannins
  • Lipids
  • ellagitannin
  • urolithin C
  • 3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one

Associated data

  • ClinicalTrials.gov/NCT01414647