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, 9 (7), e1003418

Pertussis: Challenges Today and for the Future


Pertussis: Challenges Today and for the Future

James D Cherry. PLoS Pathog.

Conflict of interest statement

The author has declared that no competing interests exist.


Figure 1
Figure 1
A: Bordetella pertussis on Ciliated Cells of Bronchus. Immunohistochemical localization of B. pertussis bacteria in the cilia of respiratory epithelium lining a bronchus of an infant who died from pertussis. Image courtesy of Christopher Paddock, M.D., Centers for Disease Control and Prevention. B: Aggregates of Leukocytes in a Pulmonary Arteriole in Pertussis. Pulmonary arteriole from an infant with fatal pertussis, showing intravascular aggregates of mixed leukocytes, comprising predominantly mature and band neutrophils, eosinophils, and monocytes. Image courtesy of Christopher Paddock, M.D., Centers for Disease Control and Prevention. C: Drawing of Bordetella pertussis on Ciliated Cells in the Trachea. Published over 100 Years Ago. Ciliated epithelium lining trachea of child dying in acute stage of whooping cough. Large numbers of minute bacilli present between the cilia. x1,000 .

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    1. Cherry JD, Heininger U (2009) Pertussis and other Bordetella infections. In: Feigin RD, Cherry JD, Demmler-Harrison GJ, Kaplan S, editors. Feigin and Cherry's textbook of pediatric infectious diseases. 6th edition. Philadelphia, PA: WB Saunders Co. pp. 1683–1706.
    1. Holmes WH (1940) Whooping-cough, or pertussis. In: Holmes WH, editor. Bacillary and rickesttsial infections acute and chronic - a textbook. New York: The MacMillan Company. pp. 395–414.
    1. Lapin JH (1943) Whooping cough. Springfield, IL: Charles C. Thomas Publishing. 112–122 p.
    1. Mattoo S, Cherry JD (2005) Molecular pathogenesis, epidemiology, and clinical manifestations of respiratory infections due to Bordetella pertussis and other Bordetella subspecies. Clin Microbiol Rev 18: 326–382. - PMC - PubMed
    1. Cherry JD, Paddock CDJ (2013) What Bordetella pertussis toxins and other proteins do and do not do in the pathogenesis of pertussis. Presented at: Pediatric Academic Scoieties Annual Meeting; May 2013; Washington, DC.

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Grant support

The author received no specific funding for this study.