Value of GATA3 Immunostaining in Tumor Diagnosis: A Review

Adv Anat Pathol. 2013 Sep;20(5):352-60. doi: 10.1097/PAP.0b013e3182a28a68.

Abstract

GATA3 is a member of a group of zinc-finger transcription factors that is involved in cell development and differentiation. Recent studies have shown that, among tumors, GATA3 is commonly expressed in both urothelial tumors and breast epithelial neoplasms. With the exception of salivary gland and parathyroid tumors, GATA3 has been reported to be either absent or only rarely expressed in other epithelial tumors. Owing to its restricted expression in urothelial and breast carcinomas, GATA3 has proved to be a useful immunohistochemical marker for assisting in distinguishing these 2 groups of neoplasms from other malignancies with which they may be confused.

Publication types

  • Review

MeSH terms

  • Antibodies
  • Biomarkers, Tumor / analysis*
  • Biopsy
  • Breast Neoplasms / chemistry
  • Breast Neoplasms / pathology
  • Carcinoma / chemistry
  • Carcinoma / pathology
  • Diagnosis, Differential
  • Female
  • GATA3 Transcription Factor / analysis*
  • Humans
  • Immunohistochemistry*
  • Male
  • Neoplasms / chemistry*
  • Neoplasms / pathology
  • Parathyroid Neoplasms / chemistry
  • Parathyroid Neoplasms / pathology
  • Predictive Value of Tests
  • Prognosis
  • Urinary Bladder Neoplasms / chemistry
  • Urinary Bladder Neoplasms / pathology
  • Urothelium / chemistry
  • Urothelium / pathology

Substances

  • Antibodies
  • Biomarkers, Tumor
  • GATA3 Transcription Factor
  • GATA3 protein, human